ODCs

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1 OMIM reference -
2 associated genes
16 signs/symptoms

PROTEIN INTERACTIONS: 1

4 OMIM references -
3 associated genes
No signs/symptoms info

Juvenile primary lateral sclerosis

Male infertility with normal virilization due to meiosis defect


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	ERLIN2	(0.63)	CFTR

Citations in the biomedical literature:

Juvenile primary lateral sclerosis		Male infertility with normal virilization due to meiosis defect
	Synonym(s): - JPLS - Juvenile PLS		Synonym(s): - Azoospermia due to maturation arrest - Azoospermia due to meiosis defect - Male infertility with normal virilization due to maturation arrest

	Classification (Orphanet): - Rare genetic disease - Rare neurologic disease		Classification (Orphanet): - Rare genetic disease

	Classification (ICD10): - Diseases of the nervous system -		Classification (ICD10): (no data available)

	Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: childhood Average age of death: any age Type of inheritance: autosomal recessive		Epidemiological data: Class of prevalence: - Average age onset: adolescence / young Average age of death: - Type of inheritance: autosomal dominant

	External references: 1 OMIM reference - 1 MeSH reference: C536416		External references: 4 OMIM references - No MeSH references

Juvenile primary lateral sclerosis
	Very frequent - Abnormal gait - Ataxia / incoordination / trouble of the equilibrium - Autosomal recessive inheritance - Hemiplegia / diplegia / hemiparesia / limb palsy - Hypereflexia - Hypertonia / spasticity / rigidity / stiffness - Motor deficit / trouble - Muscle weakness / flaccidity - Pseudobulbar signs / spasmodic laugh and cry - Pyramidal syndrome Frequent - Elocution disorders / dysarthria / dysphonia - Feeding disorder / dysphagia / swallowing / sucking disorder / esophageal dyskinesia - Speech troubles / aphasia / dysphasia / echolalia / mutism / logorrhea / dysprosodia Occasional - Bladder and ureter anomalies - Muscle hypotrophy / atrophy / dystrophy / agenesis / amyotrophy - Sensitive trouble / deficit
Male infertility with normal virilization due to meiosis defect
(no data available)